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In a large clinical study of 452 people with peripheral T-cell lymphoma, ADCETRIS plus chemotherapy (CHP) was compared to CHOP, a traditional and more commonly used chemotherapy option.
ADECTRIS plus chemotherapy lowered the overall risk of death by 34% compared to CHOP
The average follow-up time for patients in the study was 3.5 years.
Find out if ADCETRIS may be an option for you.
CHOP: A combination of 4 chemotherapies—cyclophosphamide, doxorubicin, vincristine, and prednisone.
CHP: A combination of 3 chemotherapies—cyclophosphamide, doxorubicin, and prednisone.
Complete remission: When cancer can’t be found in your body after treatment.
Partial remission: When some cancer has gone away but some is still left in your body after treatment.
ADCETRIS is not like traditional chemotherapy. It is an antibody drug conjugate made up of 3 parts: an antibody, a drug, and a linker.
An antibody that finds CD30, a protein on the surface of certain cells. Antibodies are proteins made by the body’s immune system. The antibody that makes up ADCETRIS is made in a laboratory.
A drug that is designed to cause cell death.
A linker that attaches the drug to the antibody and releases the drug inside the cell.
ADCETRIS finds and destroys cells, including peripheral T-cell lymphoma cells, that have a protein on their surface called CD30. Even though ADCETRIS is a CD30-directed treatment, it can still affect normal cells and can cause side effects. Talk to your doctor if you have more questions about possible side effects.
What is the most important serious safety information I should know about ADCETRIS?
What should I avoid when receiving ADCETRIS?
What are the other possible serious side effects of ADCETRIS?
A serious side effect can be life-threatening or can lead to death. They may happen during treatment or after your treatment has ended.
Call your doctor right away if you have symptoms of a serious side effect or if your symptoms get worse. If you have a serious side effect, your doctor may delay or stop your ADCETRIS treatment.
Your doctor will do blood tests to check your blood cell levels during ADCETRIS treatment. If your levels are too low, your doctor may lower or delay your dose, stop your ADCETRIS treatment, or give you a medicine called G-CSF. G-CSF is meant to prevent you from having a low number of white blood cells.
What were the most common side effects in patients treated with ADCETRIS?
When used alone or together with chemotherapy, the most common side effects were:
Contact your doctor if you have any other side effects that bother you or do not go away.
What should I tell my doctor before I start treatment with ADCETRIS?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.
Please see Important Facts about ADCETRIS, including IMPORTANT WARNING
What is the most important serious safety information I should know about ADCETRIS?
What should I avoid when receiving ADCETRIS?
What are the other possible serious side effects of ADCETRIS?
A serious side effect can be life-threatening or can lead to death. They may happen during treatment or after your treatment has ended.
Call your doctor right away if you have symptoms of a serious side effect or if your symptoms get worse. If you have a serious side effect, your doctor may delay or stop your ADCETRIS treatment.
Your doctor will do blood tests to check your blood cell levels during ADCETRIS treatment. If your levels are too low, your doctor may lower or delay your dose, stop your ADCETRIS treatment, or give you a medicine called G-CSF. G-CSF is meant to prevent you from having a low number of white blood cells.
What were the most common side effects in patients treated with ADCETRIS?
When used alone or together with chemotherapy, the most common side effects were:
Contact your doctor if you have any other side effects that bother you or do not go away.
What should I tell my doctor before I start treatment with ADCETRIS?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.
Please see Important Facts about ADCETRIS, including IMPORTANT WARNING