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In a study of 1334 people, ADCETRIS plus chemotherapy (AVD) was compared to traditional treatment (ABVD).
Compared to those treated with ABVD, fewer people treated with ADCETRIS plus chemotherapy (AVD) needed a stem cell transplant or more chemotherapy
Fewer people needed stem cell transplant (66 vs 99 people)
Fewer people needed more chemotherapy (36 vs 54 people)
The above information was evaluated in the study, but it was not planned for when the study started, nor was it included in the Prescribing Information.
These data are based on a median follow-up of just over 2.5 years
FDA = Food and Drug Administration
In this study, investigators performed an assessment after 5 years after the start of treatment. The results from this assessment are from an exploratory analysis and were not part of the main study. This means that the study was not designed to find differences between the 2 treatment groups after 5 years.
Find out if ADCETRIS may be an option for you.
ABVD: A combination of 4 chemotherapies—adriamycin, bleomycin, vinblastine, and dacarbazine.
AVD: A combination of 3 chemotherapies—adriamycin, vinblastine, and dacarbazine.
ADCETRIS is not like traditional chemotherapy. It is an antibody drug conjugate made up of 3 parts: an antibody, a drug, and a linker.
An antibody that finds CD30, a protein on the surface of certain cells. Antibodies are proteins made by the body’s immune system. The antibody that makes up ADCETRIS is made in a laboratory.
A drug that is designed to cause cell death.
A linker that attaches the drug to the antibody and releases the drug inside the cell.
CD30 is found on classical Hodgkin Lymphoma cells and not commonly found on healthy cells. Even though ADCETRIS is a CD30-directed therapy, it can still harm normal cells and cause side effects. Talk to your doctor if you have questions about possible side effects.
What is the most important serious safety information I should know about ADCETRIS?
What should I avoid when receiving ADCETRIS?
What are the other possible serious side effects of ADCETRIS?
A serious side effect can be life-threatening or can lead to death. They may happen during treatment or after your treatment has ended.
Call your doctor right away if you have symptoms of a serious side effect or if your symptoms get worse. If you have a serious side effect, your doctor may delay or stop your ADCETRIS treatment.
Your doctor will do blood tests to check your blood cell levels during ADCETRIS treatment. If your levels are too low, your doctor may lower or delay your dose, stop your ADCETRIS treatment, or give you a medicine called G-CSF. G-CSF is meant to prevent you from having a low number of white blood cells.
What were the most common side effects in patients treated with ADCETRIS?
When used alone or together with chemotherapy, the most common side effects were:
Contact your doctor if you have any other side effects that bother you or do not go away.
What should I tell my doctor before I start treatment with ADCETRIS?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.
Please see Important Facts about ADCETRIS, including IMPORTANT WARNING
What is the most important serious safety information I should know about ADCETRIS?
What should I avoid when receiving ADCETRIS?
What are the other possible serious side effects of ADCETRIS?
A serious side effect can be life-threatening or can lead to death. They may happen during treatment or after your treatment has ended.
Call your doctor right away if you have symptoms of a serious side effect or if your symptoms get worse. If you have a serious side effect, your doctor may delay or stop your ADCETRIS treatment.
Your doctor will do blood tests to check your blood cell levels during ADCETRIS treatment. If your levels are too low, your doctor may lower or delay your dose, stop your ADCETRIS treatment, or give you a medicine called G-CSF. G-CSF is meant to prevent you from having a low number of white blood cells.
What were the most common side effects in patients treated with ADCETRIS?
When used alone or together with chemotherapy, the most common side effects were:
Contact your doctor if you have any other side effects that bother you or do not go away.
What should I tell my doctor before I start treatment with ADCETRIS?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800-FDA-1088.
Please see Important Facts about ADCETRIS, including IMPORTANT WARNING