Could a targeted approach with ADCETRIS be right for you?

Video Transcript

ADCETRIS is not like traditional chemotherapy. It is made up of three parts: an antibody that is synthetically engineered. Normally, antibodies are proteins made by the body's immune system. In ADCETRIS, the antibody targets CD30, a protein that can be found on B and T cells, but can also be found in higher than normal amounts on cancer cells such as lymphoma cells.

The second part of ADCETRIS is a drug that is designed to cause cell death. The third and final part is a linker that attaches the drug to the antibody, then releases the drug inside the cell. ADCETRIS works in three particular steps. First, ADCETRIS targets cells that have the CD30 protein on their surface. Next, once attached, ADCETRIS is brought into the cell and released. In the third step, the drug then stops the cell from being able to grow and divide, causing the cell to die.

It's important to note that CD30 is a protein found on certain lymphoma cells and not commonly found on healthy cells.

Still, even though ADCETRIS is a CD30-directed therapy, it may still harm normal cells and cause side effects.

Indications and important safety information.

What is ADCETRIS?

ADCETRIS is a prescription medicine directed against the CD30 protein.

It is used to treat:

• Adults with previously untreated stage 3 or 4 classical Hodgkin lymphoma, in combination with chemotherapy (Adriamycin, vinblastine, and dacarbazine)
• Children two years of age and older with previously untreated high-risk classical Hodgkin lymphoma in combination with chemotherapy (doxorubicin, vincristine, etoposide, prednisone, and cyclophosphamide)
• Adults with classical Hodgkin lymphoma at high risk of coming back or becoming worse after a stem cell transplant
• Adults with classical Hodgkin lymphoma after a stem cell transplant fails or after at least two chemotherapy treatments fail and stem cell transplant is not an option
• Adults with previously untreated systemic anaplastic large cell lymphoma or other CD30-expressing peripheral T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphomas not otherwise specified in combination with chemotherapy (cyclophosphamide, doxorubicin, and prednisone)
• Adults with systemic anaplastic large cell lymphoma after at least one combination chemotherapy treatment fails
• Adults with primary cutaneous anaplastic large cell lymphoma or CD30-expressing mycosis fungoides after systemic therapy (drugs that spread throughout the body)
• Adults with relapsed or refractory large B-cell lymphoma (LBCL) including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), DLBCL arising from indolent lymphoma or high-grade B-cell lymphoma (HGBL), after two or more lines of systemic therapy who are not eligible for stem cell transplant or chimeric antigen receptor (CAR) T-cell therapy, in combination with lenalidomide and a rituximab product

Important Safety Information

What is the most important serious safety information I should know about ADCETRIS?

• Progressive Multifocal Leukoencephalopathy (PML): Patients treated with ADCETRIS can have a rare, serious brain infection, called PML that can lead to death. Tell your doctor immediately if you have mood or behavior changes, confusion, problems in thinking or loss of memory, changes in vision, speech or walking, or decreased strength or weakness on one side of the body. PML may also be caused by prior treatments or diseases that weakened your immune system.
• Do not take ADCETRIS if you are receiving bleomycin.

What are the other possible serious side effects of ADCETRIS?

• Nerve damage (peripheral neuropathy). Tell your doctor if you have any numbness or tingling in your hands or feet or any muscle weakness.
• Allergic and infusion reactions. Tell your doctor if you experience symptoms of fever, chills, rash, or breathing problems within 24 hours of infusion. If you have a reaction, you may be given medicines before your ADCETRIS treatment.
• Blood problems. Serious cases, including death, of fever with a low number of white blood cells, have occurred with ADCETRIS. Serious cases of a low number of white blood cells, a low number of platelets, or a low number of red blood cells can occur. Your doctor will do blood tests to check your blood cell levels during ADCETRIS treatment. Your doctor may give you a medicine called G-CSF. Tell your doctor if you have a fever of 100.5 degrees Fahrenheit or higher, chills, cough, or pain when you urinate.
• Infections caused by bacteria, fungi, or viruses have been reported.
• Tumor lysis syndrome is caused by the fast breakdown of cancer cells. Your doctor will monitor you for symptoms.
• Patients with severe kidney disease or moderate or severe liver disease may have more side effects and deaths than patients without kidney or liver problems.
• Liver problems. Serious liver problems, including death, can occur. Tell your doctor if you feel tired, do not feel like eating, have upper stomach pain, dark urine, or yellow skin and eyes (jaundice).
• Lung problems. Serious lung problems, including death, can occur. Tell your doctor If you have a new cough, a cough that gets worse or feel out of breath.
• Skin problems called Stevens-Johnson syndrome and toxic epidermal necrolysis can happen. Tell your doctor if you have rash, hives, sores in your mouth or blistering or peeling skin.
• Gastrointestinal (GI) problems. Serious cases, including death, related to the pancreas, stomach, intestine, and colon, can happen. If you have lymphoma that involves your stomach or intestine, you could have a higher risk of GI problems. Tell your doctor if you have severe stomach pain, chills, fever, nausea, vomiting, or diarrhea
• High blood sugar. Your doctor will test your blood during ADCETRIS treatment. Tell your doctor if you need to urinate more often than usual, are very thirsty, or have blurry vision.

The most common side effects (greater than or equal to 20%) in adult patients who received ADCETRIS are:

• nerve damage (peripheral neuropathy)
• nausea
• feeling tired
• muscle pain
• constipation
• diarrhea
• vomiting
• fever
• infection in the nose or sinuses
• sores or swelling in the mouth and/or in the digestive tract
• upper stomach pain
• rash

The most common laboratory abnormalities (greater than or equal to 20%) in adult patients who received ADCETRIS are:

• a decrease in white blood cells
• an increase in creatinine
• a decrease in hemoglobin
• an increase in blood sugars
• an increase in alanine aminotransferase (ALT)
• an increase in aspartate aminotransferase (AST)

The most common severe side effects (greater than or equal to 5%) in pediatric patients who received ADCETRIS are:

• a low number with white blood cells
• a low number of red blood cells
• a low number of platelets
• fever with a low number of white blood cells
• sores or swelling in the mouth
• infection

These are not all the possible side effects of ADCETRIS. Tell your doctor about any side effect that bothers you or does not go away. If you have certain side effects, your doctor may lower your dose, delay, or stop your ADCETRIS treatment.

What should I tell my doctor before I start treatment with ADCETRIS?

• All your medical conditions, including if you have kidney, liver, or lung problems, an infection, or diabetes.
• If you are pregnant or plan to become pregnant. ADCETRIS may harm your unborn baby. Females who are able to become pregnant: your doctor should give you a pregnancy test before starting ADCETRIS treatment. You should use effective birth control during ADCETRIS treatment and for two months after your last dose of ADCETRIS. Tell your doctor right away if you become pregnant or think you are pregnant during ADCETRIS treatment.
• Men with female partners who can get pregnant should use effective birth control during ADCETRIS treatment and for four months after the last dose.
• If you are breastfeeding or plan to breastfeed. Do not breastfeed during ADCETRIS treatment.
• All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ADCETRIS and certain other medicines can affect each other.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/Safety/MedWatch or call 1-800 FDA-1088.

Please see important facts about ADCETRIS, including BOXED WARNING.